I played the original Monkey Island 2 long ago, and loved it then. This remake gave me an excuse to play it again, and it's just as good as back then.
Gameplay-wise, it's standard fare for SCUMM engine games: you talk to people, combine stuff with other stuff, give stuff to people, and use all that to solve puzzles. The puzzles could be very head-scratching (especially a particular one towards the end of the game), but for the most part, it was manageable. Being a game focused on humor, some puzzle solutions were absolutely hilarious, once you figured them out. Compared to the original, they really didn't change too much in terms of gameplay, other than changing up the UI a bit so that it's a bit closer to Curse of Monkey Island. What I mean by this is that you have to open up an inventory screen, instead of having it present all the time on the bottom pane, and you click and hold the right mouse button over an object to get a list of options to do with it, instead of having those options always present in the bottom pane like old SCUMM games. It wasn't anything big, but I think it streamlined the gameplay a bit, not forcing you to scroll to the bottom of the screen all the time for actions, though it was annoying to switch to an inventory screen to use items all the time, especially for time-critical puzzles.
As expected, the music was redone from its original MIDI format. This works well in some places, but what made the music in orignial Monkey Island 2 really special was the seamless transitions of songs with the iMuse engine. They replicate the transitions here, but I felt that, beyond a couple of tracks (like Woodtick), the transitions in some songs as you went from one area to another in a location are a bit forced, compared to the original. This is a side effect of having pre-recorded songs play, instead of having MIDI play and change instruments/notes dynamically, but that's my only gripe.
New from this remake from the original is the voice-acting, which I felt really added to my experience, and really made it worthwhile to play the game again, after going through the orignal so many times before. As with the Secret of Monkey Island remake, you have several of the Curse of Monkey Island cast reprising their roles for recurring characters, like Dominic Armato for Guybrush and Earl Boen as LeChuck, and as always, they do a superb job. Some scenes in the game were actually a lot funnier when delivered with actual voice-acting this time.
Also expected from this remake was the overhauled graphics, which made things less pixelated, and added some frames of animations in some areas. However, despite that last bit about added animation frames, the game mostly uses the same number of animation frames as the original, which look really weird with the updated visuals. If you have ever played Street Fighter II: HD Remix, it's a similar to that, where graphics are now HD and more detailed, but the number of frames is the same as the original. It's a bit off-putting, but not too big of a deal. Walking animations for Guybrush and LeChuck have far more frames than the original, though, which looks really nice, but it's just kind of weird to have that where everything else pretty much has the same number of frames as the original game. In fact, in some places in the remake, there are less frames of animation, like with Rapp Scallion's resurrection, which was very well-animated in the original, but was choppy in the remake. I'm unsure why this is, but it bothered me why they did that.
Story-wise, this game is nothing that amazing: you're Guybrush Threepwood, a sort of loser pirate that defeated LeChuck last game, but still doesn't get any respect, so you are looking for the famous treasure, Big Whoop. The game relies mostly on humor to keep your attention, and in that regard, it does its job very well. I sometimes just replay parts of the game to go through all dialogue options, as they all typically have very interesting outcomes.
The game also includes the original version in it, which you could switch to at any time, like in Secret of Monkey Island: Special Edition. It's a nice feature for those who want to play the game in its original form.
I'd say this is a definite pick-up for any graphic adventure enthusiast, and especially for fans of the Monkey Island series or LucasArts adventure games.