Genome Guardian is a top-down roguelite turret shooter where you defend yourself from hostile aliens at the microscopic level. Combine & discover 70 weapons across 4 modes using an astounding array of turrets, perks, modifiers and power-ups on this vibrant journey to the depths of the abyss.
All Reviews:
Positive (29) - 100% of the 29 user reviews for this game are positive.
Release Date:
May 7, 2024
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About This Game





Dive into a microscopic alien world, radiating with bioluminescent life and unspeakable horrors. Genome Guardian is a deeply-complex shooter that's easy to pick up but hard to master. Research permanent upgrades to survive 70 different microbes across 4 game modes, each with multiple ascension levels ("depths").



Pair DNA nucleotides Adenine (rapidfire), Cytosine (precision), Guanine (spread), Thymine (explosive) to discover wild hybrid bioweapons!
  • Bomb + Shotgun combines explosives with spread to create Blast Shotgun!
  • Bomb + Bomb doubles down on explosive power to make Bazooka!
  • Blast Shotgun + Shotgun forms the all-powerful Flak Cannon!



  • 25 Turrets with unique strengths and functions
  • 48 Perks to mix and match that drastically change how you play
  • 72 Turret & Weapon Mods that can turn shots into sticky mines or bouncing fireballs
  • 28 Mutations that alter the challenges you face each run



  • 20-minute Runs that can be continued in Endless Mode
  • 50 Ambient & Electronic Tunes that adapt to the current mood and intensity
  • 100 Steam Achievements
  • Accessibility Settings for colourblindness and motion sickness
  • Cloud Save
  • Plays great on Steam Deck! (official Steam Deck Compatibility Review pending)

Genome Guardian is a product of passion - a culmination of everything I love about roguelite shooters, and a novel 'weapon-combining' feature that I've wanted to realize since I was a teenager. Your support will mean content updates and allow me to make more games in the future.

System Requirements

    Minimum:
    • OS: Windows 10
    • Storage: 600 MB available space
    • Additional Notes: Turn down "Render Scale" in settings if framerate is low
    Recommended:
    • OS: Windows 10
    • Storage: 600 MB available space
    • Additional Notes: Turn down "Render Scale" in settings if framerate is low

What Curators Say

10 Curators have reviewed this product. Click here to see them.

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