COMBINE WEAPONS in the microscopic roguelite turret shooter with macroscopic depth. Survive 6 modes using an astounding array of turrets, perks, mutations and power-ups on this psychedelic journey to the heart of the abyss. Shmup Mode turns it into a vertical shoot 'em up!
Recent Reviews:
Very Positive (32) - 93% of the 32 user reviews in the last 30 days are positive.
All Reviews:
Very Positive (238) - 94% of the 238 user reviews for this game are positive.
Release Date:
May 7, 2024
Developer:
Publisher:

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Curator Review

Recommended
By IndieGems May 23

“Very well designed top-down roguelite turret shooter with a genetic theme, encourages fun exploration instead of endless grind. One of the best in the genre, worth a try even if you're not into this.”

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About This Game



Dive into the microscopic world, radiating with bioluminescent life and unspeakable horrors. Genome Guardian is a deeply-complex shooter that's easy to pick up but hard to master. Research permanent upgrades to survive a variety of microbes across 6 game modes, each with multiple "depths".



Pair DNA nucleotides Adenine (rapidfire), Cytosine (precision), Guanine (spread), Thymine (explosive) to discover wild hybrid bioweapons!
  • Bomb + Shotgun combines explosives with spread to create Blast Shotgun!
  • Bomb + Bomb doubles down on explosive power to make Bazooka!
  • Blast Shotgun + Shotgun forms the all-powerful Flak Cannon!



  • 49 Turrets with unique strengths and functions
  • 96 Perks to mix and match that drastically change how you play
  • 75 Weapon & Turret Mods that can turn shots into sticky laser mines or bouncing fireballs
  • 64 Mutations alter the challenges you face each run



  • 20-minute Runs that can be continued in Endless Mode
  • 75 Bassy Electronic Tunes that adapt to the current mood & intensity
  • Cosmetics like spider legs and tank tread
  • Accessibility Settings for colourblindness, motion sickness, and even arachnophobia!
  • 100 Steam Achievements
  • Steam Trading Cards
  • Cloud Save
  • Plays great on Steam Deck!!!

System Requirements

    Minimum:
    • OS: Windows 10
    • Storage: 600 MB available space
    • Additional Notes: Turn down "Render Scale" and switch to "Low Quality" in settings if FPS is low
    Recommended:
    • OS: Windows 10
    • Storage: 600 MB available space
    • Additional Notes: Turn down "Render Scale" and switch to "Low Quality" in settings if FPS is low

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