I like the Sherlock Holmes games, but not this one. It's definitely the worst of the bunch.
First of all, you can't change the resolution. The entire game looked blurry. Sherlock's voice acting is passable, but everyone else's is laughably bad. (Also, Sherlock mispronounces "laudanum," which bothers me more than it should.)
This game commits the worst adventure game sins: pixel hunting, puzzles that are either mindless busywork or completely inscrutable, and unintuitive use of inventory items.
The game doesn't explain the rules or objectives of many puzzles. For instance, one puzzle requires you to place exactly four liters of water on a depression. You're not told that's the amount you need, which, considering there's no earthly reason that putting more weight on it wouldn't work, should really be included. One puzzle is a nonogram, something I had never seen before, and the game gave no instructions. The final puzzle is solved by randomly clicking things in your inventory, with no rhyme or reason to why that item should go there.
If you bother to play to the end, you find out that the solution to the mystery doesn't make sense and is about as ridiculous as it could get. My suggestion to anyone interested in the Sherlock Holmes games is to pass on this one and get another.