You'd expect a supreme commander to be more involved in the current events of the galaxy so as to use more than one hand, but being a supreme commander you can probably get away with it, atleast in SP

In this game you control currents in the water to guide odysseus's fleet to safety using only one hand! Great visual feedback for kids learning OHG.

This is the ultimate one hand gaming experience. Almost like an on rails shooter but instead of mindless shooting, you need to thoughtfully sign papers.

Make sure you are of legal drinking age if you want to play this game. Grab a beer and you're ready for some one hand gaming! (children also acceptable)

This game has one of the most engaging and horrifying stories in games ever. Playable with one hand on keyboard. Use beer to calm your nerves.

I like to watch the stinky snail do its business in the zen garden. What are you waiting for? Plant your hops and your wheat in one hand and lets go!

Some pirates only have one leg, but this dog has four! Also you only need one hand to play this game!

Low on cash? Let this game buy you a beer! On deathmatch simply pick your weapon of choice and wait until someone stumbles upon your spawn point!

If you're like me, you might find train simulators a bit too linear. Then why not set the train to full throttle and take a seat in one of the coaches?

Who told you to don't drink and Dwarfs!?™. The lack of a second hand might prevent you from microing your dwarfs, but in this game more chaos is good!