The main characters is an unnamed girl with unnamed Vampire-like powers.

The main character, Aluche, has inhereted Vampirism from the the first game's protagonist. She also feeds upon several other women. Second game in the Nights of Azure series.

The main character, Arnice, has a form of Vampirism (called Blood of the Night Lord) and she feeds upon the blood of the secondary lead, Lilysse. First game in the Nights of Azure series.

Alysa, a Vampire, is one of two playable main characters. The other playable character, Jeremy, is a Vampire Hunter.

Shuggy the Vampire is the main character.

Eric Bane, a Vampire, is the main character.

Based on the Tabletop-RPG Vampire: The Masquerade from the World of Darkness franchise. The player plays Julia, a Vampire.

Based on the Tabletop-RPG Vampire: The Masquerade from the World of Darkness franchise. The player chooses a Vampire out of three clans; Brujah, Toreador or Ventrue.

The Scarlet Sisters, Remilia Scarlet and Flandre Scarlet, are both playable.

The player can become a Vampire by contracting Vampirism (Noxiphilic Sanguivoria) through fighting Bloodfiends, being bitten by another Vampire player or buying the Curse of Vampirism from the store.