Experience the daily struggle to work, eat, and keep your spirit up while living as a Syrian Refugee. This can serve as a small way to build empathy towards refugees, but mild enough not to force it.

A fun Point & Click Adventure based on the Dark Eye game-verse. Part of the game takes place in Middle Eastern inspired lands and has Mid East inspired characters who even use Arabic/Pseudo-Arabic.

Caravan is a resource trading game with light RPG and storytelling aspects. If you're into trading games you'll probably like it. It takes place in a pseudo-historical Pre-Islamic Arabian Peninsula.

Only the tiniest part takes place in Iran. Gameplay is drastically different than the first game and the story is uninspired. I wouldn't normally recommend it except it's developed in Iran.

A point & click adventure in which a portion of the adventure takes place in Turkey. It has a fairly accurate depiction of a Turkish hotel and Topkapi Palace. The game itself is kind of meh though.

This game features just a small stint in Egypt but all you see is a stereotypical desert scene and you enter an "ancient Egyptian" style temple. The 3D graphics and game mechanics suck though.

Centered around the history of the Knights Templar but there's mentions of the Hashashin and part of the story takes place in 1990s Syria. Suffers from stereotypical orientalist depictions though.

DragonSphere is a fun classic P&C Adventure game. It features a very realistic bellydance scene but it's Middle Eastern based desert dwelling race is full of highly orientalist stereotypes.