You awake from billions-year cryogenic sleep to find nothing but your long-abandoned ship and its resolute and loyal AI, Lia. You find out you are the only human - all other civilizations have been destroyed by the ruthless Creeper, that has come back age after age for billions of years, fought, won and conquered many times over. It has been many thousands of years since the last civilization fell, but now it is time for you to return. You are the final, lone spark of resistance against the Creeper, which now controls the universe.
You may have no living allies, but you are at your strongest. You have Collectors and Relays to connect your vast energy networks. You have Ore Mines, Siphons and Reactors to collect and generate resources. You have Terps to terraform the land and bend the earth to your will. You have Guppies to transport packets to distant areas of the world. You have Pulse Cannons, Mortars, Strafers, Bombers, Nullifiers, Sprayers, Beams and Snipers to combat the Creeper menace. You do not risk your life by deploying your ship to the planets you land on; instead you deploy up to three packet-processing Command Nodes at a time, allowing you to maintain several outposts and strongholds on each map. You utilize the now-obselete Rift Space totems, manufacturing Aether to improve your structures, and generate a powerful Singularity Field. You build colossal Bertha cannons, blowing massive holes in oceans of Creeper.
You encounter new threats. The Creeper has corrupted human defenses and creations all across the universe. The Digitalis and Runners are just two of the many new adaptations of the Creeper.
You load your ship and prepare to venture across the universe.