Splice is a puzzle game in which you reposition cells in order to line up with an outline and create a biochemical strand. Cells are constrained by various rules and special cells such as those which duplicate or delete themselves, and it's in thinking around these that the puzzles are formed. There is a lot of playing with perspectives and intentionally attempting to overwhelm the player to mask a simple solution, which fluctuates between satisfying challenging and infuriating, with little middle ground and wild inconsistency.
Ultimately Splice's saving grace is also its downfall, and the same as virtually every game by developer Cypher Prime I've yet played, as they opt for a significant amount of style to make up for a lack in substance. The presentation is immensely cinematic, making great use of shifting planes and colors as you move from level to level, all complimented by an absolutely gorgeous piano score. It's a beautifully artistic game, but unfortunately I never found the puzzles remotely as well constructed. On the contrary, by the end I was fuming over some of the more difficult ones, and was more than happy when I was finally finished. Much of Splice's design seems dependent on confusing the player, but after a point this becomes immensely frustrating, almost as if the developers are just seeing how far they can push you without any hints or direction before you finally crack and quit the game.
My feeling on Splice are very...convoluted. The presentation is remarkable, yet the gameplay noticeably lacking. The entire time I spent with it my feelings were a mixture of awe and anger, kept only in line by a few simpler puzzles and a handy guide. I can't fully recommend it, nor can I entirely reject it, so my suggestion would be to check out the demo and see if maybe it clicks for you. If nothing else you'll get to appreciate a bit of the excellent audio and visuals, which rise so far above everything else.