Splice is a puzzle game that has an extremely high production value. The music and aesthetic of the game provide an almost ethereal feel to the player as they play it, kind of a trippy, mind-effecting theme going on. Playing it reminded me of the Cylon Basestar section of the Battlestar Galactaga series. For that alone Splice is worth playing, but the gameplay is so polished, the graphics are so sharp, and the music is so excellently packaged together with everything else I'd say it would be a shame if you didn't at least give Splice a try. I was extremely impressed with this puzzler and, while not the most head-scratchingly difficult puzzler I've ever played (it has a rewind feature a-la Braid so you can work on puzzles for as long as you want without penalty) the puzzles aren't easy and there are a lot of variables that can make you pause for a moment to think about your next action.
The gameplay of Splice is quite simple, easy to pick up, hard to master, as I always say of good puzzlers. You have a bacterial strain and move the pieces around to try and fill the silouettes provided on each level. There are "special" sections of the strain that do various things, like extend, or split the strain, duplicating the amount of cells you have. You have a lmited amount of moves to complete the puzzle; however, using "special" sections of a strain don't cost a move to use, so that adds an additional layer of strategy to Splice.
Even if the puzzles were bad (which they're not), just playing this game is a nice, chill, experience. The feeling I got while playing it reminded me a lot of playing Flow, the ambiance this game exudes is just otherworldly and really the biggest selling point of this game for me.
Come for the puzzles, stay for the experience. B+